Innovation and technology have the power to save us – if we act rapidly in multiple realms. We face daunting dilemmas – the climate crisis, war, a continuing global pandemic, refugees, and gyrating economies. But there is hope. Luckily, digital tech and science are advancing rapidly. Yet tech also contributes to societal divisions, and skeptics dare techno-optimists to prove them wrong. Techonomy 22 takes that challenge. It will forefront progress and collaboration more urgently than ever.